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Journal of Antimicrobial Chemotherapy (2002) 50, 133-136
© 2002 The British Society for Antimicrobial Chemotherapy

Effect of plaunotol in combination with clarithromycin or amoxicillin on Helicobacter pylori in vitro and in vivo

Tetsufumi Koga*, Harumi Inoue, Chika Ishii, Yoko Okazaki, Haruki Domon and Yukio Utsui

Biological Research Laboratories, Sankyo Co., Ltd, 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710, Japan

Received 22 October 2001; returned 26 February 2002; revised 10 April 2002; accepted 24 April 2002

Plaunotol, a cytoprotective anti-ulcer agent, has antibacterial activity against Helicobacter pylori. The purpose of the present study was to investigate the effect of plaunotol when combined with clarithromycin or amoxicillin against H. pylori. When combined with clarithromycin, plaunotol showed synergic activity against 11 of 14 strains, and additive activity against the other three strains, by chequerboard titration. When combined with amoxicillin, plaunotol showed additive activity against 10 of 14 strains. No antagonistic effects were seen against any of the strains tested. The interactions between plaunotol and either clarithromycin or amoxicillin were determined by time–kill assay against the Sydney Strain (strain SS1) of H. pylori. The combination of plaunotol with clarithromycin showed synergic activity and with amoxicillin showed additive activity. In a C57BL/6 mouse gastritis model infected with H. pylori SS1, the plaunotol–clarithromycin and plaunotol–amoxicillin combinations both exhibited synergic effects, which allowed the effective dose of clarithromycin to be reduced when co-administered with plaunotol. These results suggest that plaunotol may have a useful role in combination with anti-H. pylori drugs in the treatment of H. pylori-associated diseases.

* Corresponding author. Tel: +81-3-3492-3131 ext. 3516; Fax: +81-3-5485-8565; E-mail: tekoga{at}shina.sankyo.co.jp


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