Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Chen, W. N.
Right arrow Articles by Lim, G. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, W. N.
Right arrow Articles by Lim, G. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2002) 49, 1044-1046
© 2002 The British Society for Antimicrobial Chemotherapy

Correspondence

Hepatitis B virus surface antigen mutants persist in chronic carriers receiving lamivudine therapy in Singapore

Wei Ning Chen1,*, Chong Jin Oon2 and Gek Keow Lim2

1Department of Clinical Research and 2Ransome Research Laboratory, Singapore General Hospital, Singapore 169608, Republic of Singapore

Sir,

Lamivudine, the negative enantiomer of 2'-dideoxy-3'-thiacytidine, is a reverse transcriptase inhibitor for both human immunodeficiency virus (HIV) and human hepatitis B virus (HBV). Its application has so far resulted in a reduction of serum HBV DNA in chronic carriers and also improved liver function.1 However, prolonged lamivudine therapy has resulted in mutations in the Tyr-Met-Asp-Asp (YMDD) motif of the HBV DNA polymerase.2 Although the HBV DNA polymerase and viral surface antigen (HBsAg) are translated from the same coding region, albeit different reading frames, . . . [Full Text of this Article]

Acknowledgements

Footnotes

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?