Journal of Antimicrobial Chemotherapy (2002) 49, 1023-1026
© 2002 The British Society for Antimicrobial Chemotherapy
Resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime
1Microbiology Laboratories, 2Helicobacter pylori Research Institute and 3Department of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tiqva; 4Institute of Pediatric Gastroenterology and Nutrition, Schneider Children’s Medical Center of Israel, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 5Division of Epidemiology and Biostatistics, University of Illinois, Chicago, IL, USA
Received 13 November 2001; returned 21 January 2002; revised 18 February 2002; accepted 27 February 2002.
The resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime was tested in 138 isolates, including 28 from treatment failures. No resistance to tetracycline was detected. Resistance to amoxicillin was found in one isolate (MIC = 1.5 mg/L) from an untreated patient, and resistance to cefixime in two isolates from each group (P = 0.18). Resistance to metronidazole and clarithromycin was much higher in the isolates from treated than from untreated patients: 60.7% and 38.2% for metronidazole (MIC 
8 mg/L) (P = 0.03); 46.4% and 8.2% for clarithromycin (MIC 2 mg/L) (P < 0.001). Therapeutic outcome would benefit from susceptibility testing, especially after treatment failure.
* Correspondence address. Department of Clinical Microbiology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel. Tel: +972-3-937-6725; Fax: +972-3-921-8466; E-mail: zsamra{at}clalit.org.il
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