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Journal of Antimicrobial Chemotherapy (2002) 49, 1015-1018
© 2002 The British Society for Antimicrobial Chemotherapy

Characterization of clinical Streptococcus pneumoniae strains from Germany with decreased susceptibility to fluoroquinolones

Ralf René Reinert1,*, Adnan Al-Lahham1, Rudolf Lütticken1, Mechthild Boos2 and Franz-Josef Schmitz2

1Institute of Medical Microbiology, National Reference Center for Streptococci, University of Aachen, Pauwelsstrasse 30, D-52074 Aachen; 2Institute of Medical Microbiology and Virology, University Hospital Düsseldorf, Germany

Received 13 July 2001; returned 29 November 2001; revised 6 February 2002; accepted 19 February 2002.

Fourteen pneumococcal strains isolated in three nationwide studies were characterized for amino acid changes in the enzymes GyrA, GyrB, ParC and ParE, and for the in vitro activity of eight fluoroquinolones and the new non-fluorinated quinolone BMS 284756. Gemifloxacin and BMS 284756 exhibited the best in vitro activity against all 14 isolates tested. In nine of the 14 isolates mainly classical alterations in ParC (D83N/Y, S79Y/F), as well as rarer alterations such as S80P and D78N, contributed to the decreased susceptibility to fluoroquinolones. In two of the 14 isolates the classical alteration in GyrA (S81F) was found. In only one isolate did alterations in ParC and GyrA exist in parallel.

* Corresponding author. Tel: +49-241-80-89-787; Fax: +49-241-80-82-483; E-mail: reinert{at}rwth-aachen.de


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