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Journal of Antimicrobial Chemotherapy (2002) 49, 1007-1010
© 2002 The British Society for Antimicrobial Chemotherapy

Effect of matrix metalloprotease inhibitors on the 95 kDa metallopeptidase of Candida albicans

C. Imbert*, C. Kauffmann-Lacroix, G. Daniault, J. L. Jacquemin and M. H. Rodier

Unité de Recherche en Biologie Parasitaire et Fongique, Laboratoire de Parasitologie et Mycologie Médicales, CHU La Milètrie, 86021 Poitiers Cedex, France

Received 12 November 2001; returned 8 February 2002; revised 12 March 2002; accepted 14 March 2002.

A 95 kDa metallopeptidase of Candida albicans could be involved in the process of dissemination of the yeast. Matrix metalloproteases (MMPs) are also responsible for collagen breakdown in inflammatory and malignant processes. We tested six compounds on the C. albicans enzyme. Doxycycline, gentamicin, cefalothin, galardin, and elaidic and oleic acids are known for their capacity to inhibit some MMPs. Amongst these agents, only oleic acid was able to markedly inhibit the purified metallopeptidase at very low concentrations. Moreover, this fatty acid inhibited the secretion of the enzyme in the culture medium without altering the yeast viability.

* Corresponding author. Tel: +33-5-49-44-39-59; Fax: +33-5-49-44-39-08; E-mail: christine.imbert{at}univ-poitiers.fr


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