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Journal of Antimicrobial Chemotherapy (2002) 49, 879-881
© 2002 The British Society for Antimicrobial Chemotherapy

Correspondence

In vitro bactericidal activity and post-antibiotic effect of ABT-773 versus co-amoxiclav against anaerobes

Susan L. Pendland*, Melinda M. Neuhauser2 and Jennifer L. Prause1

1The University of Illinois at Chicago, College of Pharmacy, Department of Pharmacy Practice (M/C 886), Microbiology Research Laboratory, 833 South Wood Street, Chicago, IL 60612; 2The University of Houston College of Pharmacy, Department of Clinical Sciences and Administration, Houston, TX, USA

Sir,

ABT-773, a novel ketolide, has demonstrated in vitro activity against a variety of anaerobic bacteria.1–3 While several studies have investigated the susceptibility profile of ABT-773, additional data on the activity of this new ketolide against anaerobes would be useful. The purpose of this study was to compare the in vitro bactericidal activity and post-antibiotic effect (PAE) of ABT-773 and co-amoxiclav against common anaerobes.

ABT-773 (Abbott Laboratories, Abbott Park, IL, USA) and co-amoxiclav (United States Pharmacopeia, Rockville, MD, USA) powders were prepared according to NCCLS guidelines or manufacturer’s recommendations.4 The antimicrobial concentrations studied were 2 x and . . . [Full Text of this Article]

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