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Journal of Antimicrobial Chemotherapy (2002) 49, 671-674
© 2002 The British Society for Antimicrobial Chemotherapy

Brief report

In vitro bactericidal activity of ABT-773 and amoxicillin against erythromycin-susceptible and -resistant strains of Streptococcus pyogenes

Susan L. Pendlanda,*, Melinda M. Neuhauserb and Jennifer L. Prausea

a The University of Illinois at Chicago, College of Pharmacy, Department of Pharmacy Practice, Microbiology Research Laboratory, 833 South Wood Street, Chicago, IL 60612; b The University of Houston College of Pharmacy, Department of Clinical Sciences and Administration, Houston, TX, USA

The bactericidal activity of ABT-773 was compared with amoxicillin against 10 clinical isolates of S. pyogenes (six erythromycin susceptible and four erythromycin resistant). The MIC ranges (mg/L) were 0.004–0.25 of ABT-773 and 0.015–0.12 of amoxicillin. At 24 h, ABT-773 concentrations of 2 x MIC and 8 x MIC were bactericidal against three and six organisms, respectively. In comparison, amoxicillin was bactericidal against all 10 organisms at both test concentrations.

* Corresponding author. Tel: +1-312-996-8639; Fax: +1-312-413-1797; E-mail: pendland{at}uic.edu


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