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Journal of Antimicrobial Chemotherapy (2002) 49, 575-577
© 2002 The British Society for Antimicrobial Chemotherapy

Correspondence

In vitro activity of faropenem against respiratory pathogens

Mignon du Plessisa,*, Thora P. Cappera and Keith P. Klugmana,b

a Pneumococcal Diseases Research Unit of the Medical Research Council, National Health Laboratory Service and University of the Witwatersrand, de Korte Street, Hillbrow, Johannesburg 2000, South Africa; b Department of International Health, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA

Sir,

Faropenem is a novel ß-lactam antimicrobial agent sharing structural similarities with both the penicillins and cephalosporins. It exhibits a broad spectrum of activity that includes Gram-negative, Gram-positive and some anaerobic bacteria.1,2 The primary mode of action of faropenem is consistent with that of other ß-lactam antibiotics, namely binding to penicillin-binding proteins. Faropenem has been shown to demonstrate high stability to a number of ß-lactamases, including TEM-1, . . . [Full Text of this Article]

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