Journal of Antimicrobial Chemotherapy (2002) 49, 561-565
© 2002 The British Society for Antimicrobial Chemotherapy
Brief report |
A nosocomial outbreak of Pseudomonas aeruginosa isolates expressing the extended-spectrum ß-lactamase GES-2 in South Africa
a Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre; c Laboratoire de Bacteriologie, Faculté de Médecine, Université d'Auvergne, 63001 Clermont-Ferrand, France; b Department of Medical Microbiology, Faculty of Medicine, University of Pretoria, 0001 Pretoria, South Africa
Eight Pseudomonas aeruginosa clinical strains that produce the clavulanic-acid-inhibited ß-lactamase GES-2 were isolated from patients of a South African hospital from March to July 2000. They were clonally related and each harboured a 150 kb conjugative plasmid carrying a class 1 integron containing a gene cassette encoding GES-2, followed by those for ß-lactamase OXA-5 and an aminoglycoside modifying AAC(3)I-like enzyme. Hence, incidences of infection, several fatal, due to bacteria displaying clavulanate-inhibited resistance to extended-spectrum cephalosporins and reduced susceptibility to imipenem in Pretoria Academic Hospital, South Africa, can be explained, at least in part, by the spread of P. aeruginosa expressing the GES-2 ß-lactamase.
* Corresponding author. Tel: +33-1-45-21-36-32; Fax: +33-1-45-21-63-40; E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr
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