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Journal of Antimicrobial Chemotherapy (2002) 49, 531-534
© 2002 The British Society for Antimicrobial Chemotherapy

Brief report

Potential of rifamides to inhibit TNF-induced NF-{kappa}B activation

Ali A. Pahlevana,b, David J. M. Wrighta,*, Laura Bradleyb, Clive Smithb and Brian M. J. Foxwellb

a Infectious Diseases and Microbiology, Charing Cross Campus, Imperial College; b Cytokine Biology and Signal Transduction Laboratory, Kennedy Institute of Rheumatology, London, UK

Rifamides are important components in the treatment of tuberculosis. However, it is well documented that these drugs can have immunosuppressive activity, a property of these drugs that is particularly relevant to AIDS patients. In this study, we have shown that a number of rifamide analogues have the potential to block tumour necrosis factor (TNF)- or phorbol myristate acetate-induced NF-{kappa}B activation. As TNF is important in the host defence against tuberculosis, suppression of this activity may provide a potential mechanism of rifamide immunosuppressive activity.

* Correspondence address. Cell and Molecular Biology Section, Division of Biomedical Sciences, Alexander Fleming Building, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AZ, UK. Tel: +44-20-7594-3039; Fax: +44-20-8846-7261; E-mail: d.j.wright{at}ic.ac.uk


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