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Journal of Antimicrobial Chemotherapy (2002) 49, 525-529
© 2002 The British Society for Antimicrobial Chemotherapy

Liposomal amphotericin B and granulocyte colony-stimulating factor therapy in a murine model of invasive infection by Scedosporium prolificans

Montserrat Ortonedaa, Javier Capillaa, Isabel Pujolb, F. Javier Pastora, Emilio Mayayoc, Joan Fernández-Ballartd and Josep Guarroa,*

a Unitat de Microbiologia, Facultat de Medicina and Institut d'Estudis Avançats; b Laboratori de Microbiologia, Hospital Universitari de Sant Joan de Reus, Reus; c Servei de Patologia, Hospital Universitari de Tarragona Joan XXIII, Tarragona; d Unitat de Medicina Preventiva, Facultat de Medicina, Universitat Rovira i Virgili, Tarragona, Spain

We established a reproducible lethal disseminated infection by the opportunistic fungus Scedosporium prolificans in an immunosuppressed murine model. We compared the effectiveness of the combined administration of liposomal amphotericin B (LAMB) and granulocyte colony-stimulating factor (G-CSF) with that of either agent alone and with that of amphotericin B deoxycholate (AMB). LAMB + G-CSF and LAMB treatments improved survival significantly with respect to the untreated control. The mean survival times of these three groups were 13.2, 9.1 and 7.9 days, respectively. Culture results in terms of colony counts for samples of deep organs were lower in mice treated with the combined therapy, although differences were not significant. Combined LAMB + G-CSF therapy could be a promising approach for the treatment of disseminated infections of S. prolificans, although further studies are required to determine the most appropriate doses.

* Correspondence address. Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain. Tel: +34-977-759359; Fax: +34-977-759322; E-mail: umb{at}fmcs.urv.es


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