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Journal of Antimicrobial Chemotherapy (2002) 49, 489-495
© 2002 The British Society for Antimicrobial Chemotherapy

Prevalence of resistance to macrolide, lincosamide and streptogramin antibiotics in Gram-positive cocci isolated in a Korean hospital

Jung-A. Lima, Ae-Ran Kwona, Sook-Kyung Kimb, Yunsop Chongc, Kungwon Leec and Eung-Chil Choia,*

a College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742; b School of Biological Sciences, Seoul National University, Seoul 151-742; c Department of Clinical Pathology, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea

To investigate the prevalence of resistance to macrolide, lincosamide and streptogramin (MLS) antibiotics in Gram-positive cocci isolated in a Korean hospital, we tested the antibiotic susceptibility of 1097 clinical isolates of Staphylococcus aureus, coagulase-negative staphylococci (CNS) and enterococci to the macrolides erythromycin, clarithromycin, azithromycin and josamycin, the lincosamide clindamycin and the streptogramin pristinamycin. These three groups of organisms were mostly resistant to macrolides and lincosamide, but were commonly susceptible to pristinamycin. The resistance phenotypes of erythromycin-resistant isolates were determined by the double-disc test with erythromycin and clindamycin, which showed that most exhibited constitutive MLS resistance. In order to determine the prevalence of the resistance genotypes and the resistance mechanisms, the presence of the erm(A), erm(B), erm(C) and mef genes in the erythromycin-resistant isolates was identified by PCR analysis. The resistance was due mainly to the presence of erm(A) in S. aureus (82.5%), erm(B) in enterococci (55%) and erm(C) in CNS (47.2%).

* Corresponding author. Tel: +82-2-880-7874; Fax: +82-2-886-5802; E-mail: ecchoi{at}snu.ac.kr


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