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Journal of Antimicrobial Chemotherapy (2002) 49, 411-413
© 2002 The British Society for Antimicrobial Chemotherapy

Brief report

Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction

Satoshi Takeshitaa,*, Yasuo Onob, Ken Kozumaa, Masatoshi Suzukia, Yutaka Kawamuraa, Naoyuki Yokoyamaa, Taiji Furukawaa and Takaaki Isshikia

a Departments of Medicine and b Microbiology and Immunology, Teikyo University School of Medicine, Tokyo, Japan

We investigated to what extent doxycycline hydrochloride (DOXY) can modify polymorphonuclear leucocyte (PMN) activity in patients with acute myocardial infarction (AMI). PMN activity was measured in blood samples obtained at 0, 15, 30 and 60 min after DOXY administration. In patients receiving saline, PMN activity did not change over 60 min. In contrast, patients receiving DOXY showed a >=10% reduction in PMN activity at 30 and 60 min. These data support the use of DOXY to reduce myocardial cell damage by PMNs in patients with AMI.

* Correspondence address. Department of Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. Tel: +81-3-3964-1211; Fax: +81-3-5375-1308; E-mail: stake{at}blue.ocn.ne.jp


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