Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Franceschini, N.
Right arrow Articles by Amicosante, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Franceschini, N.
Right arrow Articles by Amicosante, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2002) 49, 395-398
© 2002 The British Society for Antimicrobial Chemotherapy

Brief report

Meropenem stability to ß-lactamase hydrolysis and comparative in vitro activity against several ß-lactamase-producing Gram-negative strains

N. Franceschinia, B. Segatorea, M. Perillia, S. Vessilliera, L. Franchinob and G. Amicosantea,*

a Dipartimento di Scienze e Tecnologie Biomediche, Università dell’Aquila, Via Vetoio, 67100 L’Aquila; b Medical Department AstraZeneca, Milan, Italy

The interaction between meropenem and class A, B, C and D ß-lactamases was studied by a spectrophotometric method. Class A, C and D ß-lactamases were unable to confer in vitro resistance to carbapenems. Surprisingly, several class B metallo-ß-lactamases expressed in Escherichia coli failed to confer resistance when a conventional inoculum (105 cfu/mL) was used.

* Corresponding author. Tel: +39-0862-433455; Fax: +39-0862-433433; E-mail: amicosante{at}cc.univaq.it


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.