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Journal of Antimicrobial Chemotherapy (2002) 49, 331-335
© 2002 The British Society for Antimicrobial Chemotherapy

ß-Lactam modification of the bacteraemic profile and its relationship with mortality in a pneumococcal mouse sepsis model

J. Yustea, I. Jadoa, A. Fenolla, L. Aguilarb, M. J. Giménezb and J. Casala,*

a Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo, Km. 2, 28220 Majadahonda, Madrid; b Medical Department, GlaxoSmithkline, Tres Cantos, Madrid, Spain

A sepsis BALB/c mice model was used to investigate the relationship between mortality and the bacteraemic profile produced by a serotype 6B Streptococcus pneumoniae clinical isolate (MIC/MBC of amoxicillin 4/4 mg/L and of cefotaxime 2/4 mg/L). Animals were treated subcutaneously with doses of amoxicillin or cefotaxime ranging from 6.25 to 50 mg/kg tds for 48 h, starting 1 h after intraperitoneal inoculation (2 x 107 cfu/mouse). Blood cultures were carried out daily over 15 days. A survival rate of 100% was obtained with amoxicillin 25 mg/kg and of 60% with cefotaxime 50 mg/kg. A statistically significant (P = 0.012) relationship was found between the maximum cfu/mL in blood and mortality. A maximum log cfu/mL of 6.5 was associated with an 84% probability of death.

* Corresponding author. Tel: +34-91-509-7975; Fax: +34-91-509-7966; E-mail: jcasal{at}isciii.es


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