Journal of Antimicrobial Chemotherapy (2002) 49, 235-238
© 2002 The British Society for Antimicrobial Chemotherapy
Leading articles |
New antimicrobials in the management of cystic fibrosis
Department of Clinical Microbiology and Danish Cystic Fibrosis Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej, Copenhagen, Denmark
The chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) is a biofilm1 characterized by (i) the mucoid phenotype producing an abundance of alginate in vitro and in the patients, (ii) microcolonies surrounded by alginate in sputum and in post-mortem investigations and bacteria staying on the surface of the airways as an endobronchiolitis without spreading to the blood or to other organs, (iii) high levels of antibodies against alginate and other P. aeruginosa antigens, and (iv) resistance to the patients' defence mechanisms and to antibiotic treatment.1 Oxygen radicals produced by the inflammatory response (polmorphonuclear leucocytes; PMNs) induce mutations leading to the alginate production that is so characteristic of P. aeruginosa biofilm infection in CF.2 Quorum sensing is also involved in mature biofilm formation in vitro and in vivo.3 The biofilm mode of growth is the survival strategy of environmental bacteria such as P. aeruginosa, and alginate biofilms are
P. aeruginosa biofilms and antibiotics
Conventional resistance mechanisms in P. aeruginosa biofilms
Current therapeutic strategies for P. aeruginosa biofilm infection
New therapeutic strategies for P. aeruginosa biofilm infection
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