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Journal of Antimicrobial Chemotherapy (2002) 49, 193-196
© 2002 The British Society for Antimicrobial Chemotherapy

Brief report

Therapeutic efficacy of intraperitoneal polymyxin B and polymyxin-like peptides alone or combined with levofloxacin in rat models of septic shock

Andrea Giacomettia, Oscar Cirionia,*, Roberto Ghisellib, Federico Mocchegianib, Alessandra Mataloni Paggia, Fiorenza Orlandoc, Wojciech Kamyszd, Franciszek Kasprzykowskid, Zbigniew Mackiewiczd, Giorgio Scalisea and Vittorio Sabab

a Institute of Infectious Diseases and Public Health, University of Ancona, Ancona; b Department of General Surgery 1, INRCA IRRCS, University of Ancona, Ancona; c Biotechnology Centre, Research Department, INRCA IRRCS, Ancona, Italy; d Faculty of Chemistry, University of Gdansk, Gdansk, Poland

The efficacy of two polymyxin-like peptides, KFFKFFKFF and IKFLKFLKFL, alone and combined with levofloxacin, was investigated in a rat model of septic shock. Rats were given an ip injection of 2 x 1010 cfu of Escherichia coli and randomized to receive ip isotonic sodium chloride solution, 7 mg/kg levofloxacin, 1 mg/kg polymyxin B and 1 mg/kg of each polymyxin-like peptides alone or combined with 7 mg/kg levofloxacin. Polymyxins achieved a significant reduction in plasma endotoxin and tumour necrosis factor {alpha} (TNF-{alpha}) concentration. Levofloxacin significantly reduced the bacterial growth and TNF-{alpha} concentration. The combinations of polymyxin-like peptides and levofloxacin demonstrated the highest efficacy.

* Correspondence address. Clinica delle Malattie Infettive, c/o Ospedale Regionale, via Conca, 60020 Ancona, Italy. Tel: +39-071-5963715; Fax: +39-071-5963468; E-mail: anconacmi{at}interfree.it


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