Journal of Antimicrobial Chemotherapy (2002) 49, 173-176
© 2002 The British Society for Antimicrobial Chemotherapy
Brief report |
Fluoroquinolone resistance among clinical isolates of Streptococcus pneumoniae belonging to international multiresistant clones
a Pneumococcal Diseases Research Unit of the Medical Research Council, The South African Institute for Medical Research and the University of the Witwatersrand, Johannesburg, South Africa; b Northern Ireland Public Health Laboratory, Belfast City Hospital, Belfast, UK; c Department of International Health, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
Twenty-nine fluoroquinolone (FQ)-resistant clinical isolates of Streptococcus pneumoniae from a collection of isolates from the Alexander Project (1992–1997) and a study from Northern Ireland were identified on the basis of ofloxacin MICs 
4 mg/L. DNA fingerprint analyses using BOX-fingerprinting and pulsed-field gel electrophoresis revealed serotype 9V and 23F high-level FQ-resistant strains indistinguishable from the pandemic Spain23F-1 and Spain9V-3 clones, the type strains of which are low-level resistant or susceptible to the fluoroquinolones.
* Correspondence address. Department of Clinical Microbiology and Infectious Diseases, SAIMR, PO Box 1038, Johannesburg 2000, South Africa. Tel: +27-11-4899335; Fax: +27-11-4899332; E-mail: lesmcgee{at}hotmail.com
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