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Journal of Antimicrobial Chemotherapy (2001) 48, 5-16
© 2001 The British Society for Antimicrobial Chemotherapy


Supplement

Determination of minimum inhibitory concentrations

Jennifer M. Andrews*,1

1 Department of Microbiology, City Hospital NHS Trust, Birmingham B18 7QH, UK

Abstract

Minimum inhibitory concentrations (MICs) are defined as the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation, and minimum bactericidal concentrations (MBCs) as the lowest concentration of antimicrobial that will prevent the growth of an organism after subculture on to antibiotic-free media. MICs are used by diagnostic laboratories mainly to confirm resistance, but most often as a research tool to determine the in vitro activity of new antimicrobials, and data from such studies have been used to determine MIC breakpoints. MBC determinations are undertaken less frequently and their major use has been reserved for isolates from the blood of patients with endocarditis. Standardized methods for determining MICs and MBCs are described in this paper. Like all standardized procedures, the method must be adhered to and may not be adapted by the user. The method gives information on the storage of standard antibiotic powder, preparation of stock antibiotic solutions, media, preparation of inocula, incubation conditions, and reading and interpretation of results. Tables giving expected MIC ranges for control NCTC and ATCC strains are also supplied.

Notes

* Tel: +44-121-507-5693; Fax: +44-121-551-7763; E-mail: Jenny.Andrews{at}cityhospbham.wmids.nhs.uk


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E. Batard, M. E. Juvin, C. Jacqueline, D. Bugnon, J. Caillon, G. Potel, and H. B. Drugeon
Influence of Carbon Dioxide on the MIC of Telithromycin for Streptococcus pneumoniae: an In Vitro-In Vivo Study
Antimicrob. Agents Chemother., January 1, 2005; 49(1): 464 - 466.
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J Antimicrob ChemotherHome page
T. S. J. Elliott, J. Foweraker, F. K. Gould, J. D. Perry, and J. A. T. Sandoe
Guidelines for the antibiotic treatment of endocarditis in adults: report of the Working Party of the British Society for Antimicrobial Chemotherapy
J. Antimicrob. Chemother., December 1, 2004; 54(6): 971 - 981.
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J. Clin. Microbiol.Home page
M. P. Crespo, N. Woodford, A. Sinclair, M. E. Kaufmann, J Turton, J. Glover, J. D. Velez, C. R. Castaneda, M. Recalde, and D. M. Livermore
Outbreak of Carbapenem-Resistant Pseudomonas aeruginosa Producing VIM-8, a Novel Metallo-{beta}-Lactamase, in a Tertiary Care Center in Cali, Colombia
J. Clin. Microbiol., November 1, 2004; 42(11): 5094 - 5101.
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D. J. Eaves, L. Randall, D. T. Gray, A. Buckley, M. J. Woodward, A. P. White, and L. J. V. Piddock
Prevalence of Mutations within the Quinolone Resistance-Determining Region of gyrA, gyrB, parC, and parE and Association with Antibiotic Resistance in Quinolone-Resistant Salmonella enterica
Antimicrob. Agents Chemother., October 1, 2004; 48(10): 4012 - 4015.
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Appl. Environ. Microbiol.Home page
L. Vali, K. A. Wisely, M. C. Pearce, E. J. Turner, H. I. Knight, A. W. Smith, and S. G. B. Amyes
High-Level Genotypic Variation and Antibiotic Sensitivity among Escherichia coli O157 Strains Isolated from Two Scottish Beef Cattle Farms
Appl. Envir. Microbiol., October 1, 2004; 70(10): 5947 - 5954.
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J Antimicrob ChemotherHome page
L. P. Randall, S. W. Cooles, L. J. V. Piddock, and M. J. Woodward
Mutant prevention concentrations of ciprofloxacin and enrofloxacin for Salmonella enterica
J. Antimicrob. Chemother., September 1, 2004; 54(3): 688 - 691.
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J Antimicrob ChemotherHome page
P. Seaman, M. Day, A. D. Russell, and D. Ochs
Susceptibility of capsular Staphylococcus aureus strains to some antibiotics, triclosan and cationic biocides
J. Antimicrob. Chemother., September 1, 2004; 54(3): 696 - 698.
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J Antimicrob ChemotherHome page
R. Reynolds, N. Potz, M. Colman, A. Williams, D. Livermore, A. MacGowan, and on behalf of the BSAC Extended Working Party on Ba
Antimicrobial susceptibility of the pathogens of bacteraemia in the UK and Ireland 2001-2002: the BSAC Bacteraemia Resistance Surveillance Programme
J. Antimicrob. Chemother., June 1, 2004; 53(6): 1018 - 1032.
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M. M. Tunney, G. Ramage, T. R. Field, T. F. Moriarty, and D. G. Storey
Rapid Colorimetric Assay for Antimicrobial Susceptibility Testing of Pseudomonas aeruginosa
Antimicrob. Agents Chemother., May 1, 2004; 48(5): 1879 - 1881.
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J Antimicrob ChemotherHome page
N. A. C. Potz, S. Mushtaq, A. P. Johnson, C. J. Henwood, R. A. Walker, E. Varey, M. Warner, D. James, and D. M. Livermore
Reliability of routine disc susceptibility testing by the British Society for Antimicrobial Chemotherapy (BSAC) method
J. Antimicrob. Chemother., May 1, 2004; 53(5): 729 - 738.
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J Antimicrob ChemotherHome page
F. Walsh, F. Carnegy, J. Willcock, and S. Amyes
Comparative in vitro activity of telithromycin against macrolide-resistant and -susceptible Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae
J. Antimicrob. Chemother., May 1, 2004; 53(5): 793 - 796.
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D. J. Eaves, V. Ricci, and L. J. V. Piddock
Expression of acrB, acrF, acrD, marA, and soxS in Salmonella enterica Serovar Typhimurium: Role in Multiple Antibiotic Resistance
Antimicrob. Agents Chemother., April 1, 2004; 48(4): 1145 - 1150.
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Antimicrob. Agents Chemother.Home page
V. Ricci, M. L. Peterson, J. C. Rotschafer, H. Wexler, and L. J. V. Piddock
Role of Topoisomerase Mutations and Efflux in Fluoroquinolone Resistance of Bacteroides fragilis Clinical Isolates and Laboratory Mutants
Antimicrob. Agents Chemother., April 1, 2004; 48(4): 1344 - 1346.
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J Antimicrob ChemotherHome page
N. A. C. Potz, M. Colman, M. Warner, R. Reynolds, and D. M. Livermore
False-positive extended-spectrum {beta}-lactamase tests for Klebsiella oxytoca strains hyperproducing K1 {beta}-lactamase
J. Antimicrob. Chemother., March 1, 2004; 53(3): 545 - 547.
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J Antimicrob ChemotherHome page
R. Reynolds, J. Shackcloth, D. Felmingham, A. MacGowan, and on behalf of the BSAC Extended Working Party on Re
Comparison of BSAC agar dilution and NCCLS broth microdilution MIC methods for in vitro susceptibility testing of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis: the BSAC Respiratory Resistance Surveillance Programme
J. Antimicrob. Chemother., December 1, 2003; 52(6): 925 - 930.
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J Antimicrob ChemotherHome page
R. Reynolds, J. Shackcloth, D. Felmingham, A. MacGowan, and on behalf of the BSAC Extended Working Party on Re
Antimicrobial susceptibility of lower respiratory tract pathogens in Great Britain and Ireland 1999-2001 related to demographic and geographical factors: the BSAC Respiratory Resistance Surveillance Programme
J. Antimicrob. Chemother., December 1, 2003; 52(6): 931 - 943.
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J Antimicrob ChemotherHome page
N. Woodford, R. Reynolds, J. Turton, F. Scott, A. Sinclair, A. Williams, and D. Livermore
Two widely disseminated strains of Enterococcus faecalis highly resistant to gentamicin and ciprofloxacin from bacteraemias in the UK and Ireland
J. Antimicrob. Chemother., October 1, 2003; 52(4): 711 - 714.
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