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Journal of Antimicrobial Chemotherapy (2001) 48, 923-926
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Localization of [14C]amoxicillin in rat gastric tissue when administered with lansoprazole and clarithromycin

H. Endo,*, H. Yoshida, N. Ohmi, K. Ohta and S. Higuchi

Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403 Yoshino-cho 1-chome, Saitama-shi, Saitama 330-8530, Japan

The gastric mucosal distribution of [14C]amoxicillin when administered to rats with or without lansoprazole and clarithromycin was investigated. After oral administration, the amount found in the gastric mucosa was higher than after iv administration. Co-administration of lansoprazole and clarithromycin had no apparent effect on the distribution pattern of [14C]amoxicillin within the deeper stomach layers. About 50–60% of the radioactivity in the gastric tissue was present in the mucosal layer, irrespective of the route of administration. Microautoradiograms of the gastric mucosa indicated that [14C]amoxicillin was distributed in both the mucous layer and surface epithelial cells following oral administration. [14C]amoxicillin was secreted mainly by surface epithelial cells after iv administration, although only in small quantities.

* Corresponding author. Tel: +81-48-663-1111; Fax: +81-48-652-7254; E-mail: hiromi.endou{at}po.rd.taisho.co.jp


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H. Endo, H. Yoshida, N. Ohmi, K. Ohta, S. Higuchi, and T. Suga
Localization of [14C]clarithromycin in rat gastric tissue when administered with lansoprazole and amoxicillin
J. Antimicrob. Chemother., August 1, 2002; 50(2): 285 - 288.
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