Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Balcabao, I. P.
Right arrow Articles by Prieto, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Balcabao, I. P.
Right arrow Articles by Prieto, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2001) 48, 907-909
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Influence of the decrease in ciprofloxacin susceptibility and the presence of human serum on the in vitro susceptibility of Streptococcus pneumoniae to five new quinolones

I. P. Balcabaoa, L. Aloua, L. Aguilarb, M. L. Gomez-Lusa, M. J. Giménezb and J. Prietoa,*

a Microbiology Department, School of Medicine, Universidad Complutense, 28040 Madrid; b Medical Department, GlaxoSmithKline, Tres Cantos, Madrid, Spain

Sixty recent Streptococcus pneumoniae isolates with different susceptibilities to ciprofloxacin (14 with MIC 0.5 mg/L, 10 with MIC 1 mg/L, eight with MIC 2 mg/L, 11 with MIC 4 mg/L and 17 with MIC >=8 mg/L) were tested against five new quinolones using Todd–Hewitt broth with and without 80% serum. The final inoculum was 5 x 105 cfu/mL. Gemifloxacin and clinafloxacin exhibited the lowest MIC90 values and resistance rates (percentage above and defined breakpoint) with and without serum for strains with a ciprofloxacin MIC of >=4 mg/L. Other quinolones tested were less active against strains with reduced ciprofloxacin susceptibility. The presence of serum did not affect susceptibility to moxifloxacin, but increased the resistance rates to other new quinolones for strains with high ciprofloxacin MICs.

* Corresponding author. Tel: +34-91-394-15-08, Fax: +34-91-394-15-11; E-mail: jprieto{at}med.ucm.es


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
D. Sevillano, L. Aguilar, L. Alou, M.-J. Gimenez, O. Echevarria, F. Cafini, E. Valero, A. Fenoll, and J. Prieto
Effects of antimicrobials on the competitive growth of Streptococcus pneumoniae: a pharmacodynamic in vitro model approach to selection of resistant populations
J. Antimicrob. Chemother., October 1, 2006; 58(4): 794 - 801.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
L. Alou, M.-J. Gimenez, D. Sevillano, L. Aguilar, F. Cafini, O. Echeverria, E. Perez-Trallero, and J. Prieto
A pharmacodynamic approach to antimicrobial activity in serum and epithelial lining fluid against in vivo-selected Streptococcus pneumoniae mutants and association with clinical failure in pneumonia
J. Antimicrob. Chemother., August 1, 2006; 58(2): 349 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
G. E. Stein, S. Schooley, K. L. Tyrrell, D. M. Citron, and E. J. C. Goldstein
Bactericidal Activities of Methoxyfluoroquinolones Gatifloxacin and Moxifloxacin against Aerobic and Anaerobic Respiratory Pathogens in Serum
Antimicrob. Agents Chemother., April 1, 2003; 47(4): 1308 - 1312.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
O. Dobay, F. Rozgonyi, E. Hajdu, E. Nagy, M. Knausz, and S. G. B. Amyes
Antibiotic susceptibility and serotypes of Streptococcus pneumoniae isolates from Hungary
J. Antimicrob. Chemother., April 1, 2003; 51(4): 887 - 893.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.