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Journal of Antimicrobial Chemotherapy (2001) 48, 705-707
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Antimycobacterial activity of N1-{1-[3-aryl-1-(pyridin-2-, 3- or 4-yl)-3-oxo] propyl}-2-pyridinecarboxamidrazones

E. Banfia,*, M. G. Mamolob, D. Zampierib, L. Viob and C. Monti Bragadina

a Dipartimento di Scienze Biomediche (sez. Microbiologia), Università di Trieste, via A. Fleming 22, I-34127 Trieste; b Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy

Infections caused by non-tuberculous mycobacteria and multidrug-resistant Mycobacterium tuberculosis are difficult to treat, and so new compounds potentially active against these bacteria are being sought. A series of 2-pyridinecarboxamidrazone derivatives, recently synthesized, have been evaluated for their inhibitory activity against 17 Mycobacterium avium isolates; the agar dilution method showed different degrees of susceptibility to the new molecules. Four molecules, three of which are chlorine derivatives, inhibited 94% of the strains tested with an MIC of 32 mg/L. These data indicate that these new pyridine-2-carboxamidrazones merit further study as antimycobacterial agents.

* Corresponding author. Tel: +39-40-6767187; Fax: +39-40-351668; E-mail: banfi{at}dsbmail.units.it


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