Journal of Antimicrobial Chemotherapy (2001) 48, 627-630
© 2001 The British Society for Antimicrobial Chemotherapy
An integron-associated ß-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum ß-lactamase IBC-1
a Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens; b Department of Microbiology, Medical School, Aristotle University of Thessaloniki; c Department of Microbiology, Hippokration General Hospital, Thessaloniki; d Department of Microbiology, Medical School, University of Athens, Athens, Greece
An extended-spectrum ß-lactamase, IBC-2, produced by a clinical strain of Pseudomonas aeruginosa, was characterized. blaIBC-2 was found, as a gene cassette, to be the sole gene within the variable region of a class 1 integron probably located in the chromosome. IBC-2 is a variant of IBC-1 and GES-1, differing by one amino acid from each of these ß-lactamases. When expressed in Escherichia coli, IBC-2 was observed to confer resistance to ceftazidime and decreased susceptibility to other oxyimino-ß-lactams.
* Correspondence address. Laboratory of Antimicrobial Agents, Department of Microbiology, Medical School, National University of Athens, M. Asias 75, Athens 115, Greece. Tel: +30-1-778-5638; Fax: +30-1-770-9180; E-mail: Ltzouvel{at}cc.uoa.gr
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