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Journal of Antimicrobial Chemotherapy (2001) 48, 445-446
© 2001 The British Society for Antimicrobial Chemotherapy

Correspondence

Intracellular penetration and bactericidal activity of the novel des-fluoro(6) quinolone, BMS-284756

Benjamin Kolek, Glenn Warr, Daniel Bonner and Joan Fung-Tomc,*

Department of Microbiology, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492, USA

Sir,

Many organisms of clinical importance, such as mycobacterium, chlamydia, legionella and Staphylococcus aureus, are intracellular pathogens. These intracellular organisms are inhibited only by antimicrobial agents that can achieve high levels in phagocytic cells. Quinolones generally have good intracellular uptake into phagocytes, with a cellular to extracellular ratio (C/E) of c. 5–10.1 In this study, the penetration of the novel des-fluoro(6) quinolone BMS-284756 . . . [Full Text of this Article]

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