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Journal of Antimicrobial Chemotherapy (2001) 48, 417-420
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Effect of serum from different patient populations on the serum bactericidal test

Michael B. Kaysa,*, Roger L. Whiteb and Lawrence V. Friedrichb

a Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University, Indianapolis, IN; b Anti-infective Research Laboratory, College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA

We evaluated the effect of serum from normal and uraemic volunteers, neutropenic patients and burn patients on the serum bactericidal test. Serum samples were spiked with ceftazidime to mimic in vivo peak (75 mg/L) and trough (5 mg/L) concentrations. Serum inhibitory and bactericidal titres (SIT and SBT) were performed in triplicate using Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. For E. coli, the trough SIT and SBT were significantly higher in serum from burn patients compared with normal volunteers (P <= 0.024). The trough SIT was significantly higher in serum from burn patients compared with neutropenic patients (P = 0.022) and in uraemic patients compared with normal volunteers (P = 0.04). No significant differences between subject populations were found for P. aeruginosa.

* Correspondence address. Purdue University School of Pharmacy, Department of Pharmacy Practice, D711 Myers Building, WHS, 1001 West Tenth Street, Indianapolis, IN 46202-2879, USA. Tel: +1-317-613-2315, ext. 319; Fax: +1-317-613-2316; E-mail: mkays{at}iupui.edu


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