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Journal of Antimicrobial Chemotherapy (2001) 48, 316-317
© 2001 The British Society for Antimicrobial Chemotherapy

Correspondence

First clinical isolate of Streptococcus pneumoniae exhibiting high-level resistance to fluoroquinolones in Taiwan

Po-Ren Hsueha,b, Lee-Jene Tenga,c,*, Tsu-Lan Wud, Shen-Wu Hoa,c and Kwen-Tay Luha,b

a Departments of Laboratory Medicine and b Internal Medicine, National Taiwan University Hospital; c School of Medical Technology, National Taiwan University College of Medicine, Taipei; d Chang Gung Memorial Hospital, Lin-Kou, Taiwan

Sir,

The increasing resistance to fluoroquinolones among Streptococcus pneumoniae has been noted worldwide. Bacterial resistance to fluoroquinolones originates from point mutations at the highly conserved amino acid residues in the quinolone resistance-determining regions (QRDRs) of the gyrA subunit of DNA gyrase and the parC subunit of DNA topoisomerase IV.1–3 In addition, an active efflux mechanism may contribute . . . [Full Text of this Article]

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