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Journal of Antimicrobial Chemotherapy (2001) 48, 145-148
© 2001 The British Society for Antimicrobial Chemotherapy

Correspondence

Comparative in vitro study of the activity of moxifloxacin and other antibiotics against 150 strains of penicillin non-susceptible Streptococcus pneumoniae and against 110 strains of ampicillin-resistant Haemophilus influenzae isolated in 1999–2000 in Spain

J. I. Alós*,, J. Oteo, B. Aracil and J. L. Gómez-Garcés

Servicio de Microbiología, Hospital de Móstoles, 28935 Móstoles, Madrid, Spain

Sir,

Antimicrobial resistance amongst strains of Haemophilus influenzae and Streptococcus pneumoniae has limited the usefulness of first-line agents in some clinical settings. There is thus a clear need for new antibiotics, in particular those active against resistant strains. Moxifloxacin is an 8-methoxyquinolone with high activity against Grampositive bacteria, including penicillin-intermediate and -resistant pneumococci.1,2 As with earlier fluoroquinolones, moxifloxacin shows excellent activity against H. influenzae.1,2 Moxifloxacin has a bactericidal effect against both pathogens, and its post-antibiotic effect was similar to that of other fluoroquinolones and increased with increasing concentrations.3

The aim of this study was to assess the antimicrobial susceptibility to moxifloxacin and 14 other . . . [Full Text of this Article]

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