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Journal of Antimicrobial Chemotherapy (2001) 48, 141-142
© 2001 The British Society for Antimicrobial Chemotherapy

Correspondence

Dormancy and persistence in chronic infection: role of the general stress response in resistance to chemotherapy

Michael R. W. Brown and Anthony W. Smith

Microbiology Research Group, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK

Sir,

In a recent correspondence, Dick1 usefully refers to phenotypic antibiotic resistance in Mycobacterium tuberculosis related to dormancy, the possibility of anti-dormancy drug targets and problems of susceptibility assays. In this context it would be helpful to draw attention to the wider implications of dormancy in persistence and chronic infection in general. Such infections are commonly associated with biofilm/biomass . . . [Full Text of this Article]

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