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Journal of Antimicrobial Chemotherapy (2001) 48, 131-135
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

In vitro and in vivo efficacy of a novel fluoro-ketolide HMR 3562 against enterococci

Michele Guitton, Carole Delachaume, Pascal Le Priol, Valérie Steier and Alain Bonnefoy*,

Aventis Pharma, Infectious Diseases Group, Microbiology, 102, Route de Noisy, 93235 Romainville Cedex, France

The in vitro activity of HMR 3562, a new 2-fluoro-ketolide drug, was investigated against 95 enterococci, including 36 vancomycin-resistant strains. HMR 3562 inhibited 90% of enterococci susceptible or resistant to erythromycin A at 0.005 and 0.6 mg/L, respectively. HMR 3562 was highly active in murine peritonitis induced by five enterococci, irrespective of resistance phenotype, displaying effective doses in the range 3.4–21.8 mg/kg. The results demonstrate the potential of HMR 3562 in the treatment of infections caused by multiresistant enterococci.

* Corresponding author. Tel: +33-1-49-91-47-78; Fax: +33-1-49-91-50-61; E-mail: Alain.Bonnefoy{at}aventis.com


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