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Journal of Antimicrobial Chemotherapy (2001) 48, 121-125
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Interpretative criteria and quality control parameters for telithromycin disc diffusion susceptibility tests

Arthur L. Barry*,, Peter C. Fuchs and Steven D. Brown

The Clinical Microbiology Institute, 9725 SW Commerce Circle, Wilsonville, OR 97070, USA

In vitro studies were carried out with 4175 Gram-positive clinical isolates, comparing telithromycin broth microdilution MICs with disc diffusion zone diameters. Provisional interpretive criteria for testing staphylococci were >=23 mm for susceptible and <=19 mm for resistant. Because pneumococci and other streptococci require increased CO2, the corresponding zone sizes are 3 mm smaller (>=20 mm and <=16 mm). Two collaborative studies were performed in order to propose the following quality control limits: 24–30 mm for Staphylococcus aureus ATCC 25923 and 27–33 mm for Streptococcus pneumoniae ATCC 49619.

* Corresponding author. Tel: +1-503-682-3232; Fax: +1-503-682-2065; E-mail: cmi{at}hevanet.com


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