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Journal of Antimicrobial Chemotherapy (2001) 47, 867-870
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

The effect of azithromycin and clarithromycin on ex vivo interleukin-8 (IL-8) release from whole blood and IL-8 production by human alveolar macrophages

Anna Kurdowskaa,*, James M. Noblea and David E. Griffithb

a Departments of Biochemistry and b Medicine, University of Texas Health Center at Tyler, Tyler, 11937 US Highway 271, TX 75708-3154, USA

We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages. Ex vivo stimulation of leukocytes with either of the antibiotics (0.04–40 mg/L) significantly increased IL-8 secretion. Incubation of alveolar macrophages with different concentrations of azithromycin or clarithromycin modified IL-8 production: it increased at a drug concentration of 4 mg/L and decreased at concentration of 400 mg/L. Our findings suggest that azithromycin and clarithromycin may alter IL-8 production, thus enhancing the clinical effectiveness of these antibiotics.

* Corresponding author. Tel: +1-903-877-7738; Fax: +1-903-877-5101; E-mail: anna.kurdowska{at}uthct.edu


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