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Journal of Antimicrobial Chemotherapy (2001) 47, 711-713
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Pancreatic concentrations of cefepime

R. Delcenseriea,*, M. P. Dellion-Lozingueza, T. Yzeta, B. Lepointeb, L. Haryc, R. Badouib, P. Verhaeghed, M. Andrejakc and J. L. Dupasa

a Services d'Hépatogastroentérologie, b d'Anesthésie-Réanimation, c de Pharmacovigilance and d de Chirurgie A, Centre Hospitalo-Universitaire Nord, 80054 Amiens Cedex, France

The concentrations of cefepime in pancreatic pseudocyst fluid (n = 4), pancreatic tissue (n = 4) and pancreatic fistula fluid (n = 1), and simultaneous plasma concentrations, were measured after intravenous administration of a single 2 g dose to nine patients. Mean plasma concentration was 27.4 mg/L between 120 and 200 min after the end of infusion. Mean pancreatic cefepime concentration was 6.3 mg/L in pseudocyst and 10.7 mg/L in pancreatic tissue. Cefepime was detected by 30 min after the end of the perfusion in pancreatic fistulae fluid, and persisted at 8 h. We conclude that cefepime is a potentially useful antibiotic in prevention and treatment of pancreatic infection.

* Corresponding author. Tel: +33-3-22-66-82-12; Fax: +33-3-22-66-82-18; E-mail: delcenserie.richard{at}chu-amiens.fr


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