Journal of Antimicrobial Chemotherapy (2001) 47, 709-710
© 2001 The British Society for Antimicrobial Chemotherapy
Brief report |
Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans
a Departments of Infectious Diseases and b Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan; c Food Functionality Research Institute, Meiji Milk Products Co. Ltd, Higashimurayama, Tokyo 189-8530, Japan
To examine the efficacy of Lactobacillus gasseri OLL2716 (LG21) as a probiotic for Helicobacter pylori in humans, 31 subjects infected with the bacterium ingested yogurt containing LG21 daily for an 8 week period. The [13C]urea breath test and assays of serum pepsinogens revealed a significant improvement following LG21 treatment. LG21 was thus determined to be effective in both suppressing H. pylori and reducing gastric mucosal inflammation.
* Corresponding author. Tel: +81-463-93-1121 Ext: 2591; Fax: +81-463-94-2976; E-mail: yasuhiro{at}is.icc.u-tokyo.ac.jp
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