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Journal of Antimicrobial Chemotherapy (2001) 47, 697-699
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

The effect of Escherichia coli heat-stable toxin on the trans-epithelial intestinal elimination of ciprofloxacin in the rabbit

Albert Musafijaa, Yuri Shtelmana, Jacob Ramonb, Moshe Volkc, Shlomo Segeva and Ethan Rubinsteina,*

a The Infectious Diseases Unit, b Department of Urology, Sheba Medical Center, Tel Hashomer 52621, Tel Aviv University School of Medicine; c Central Laboratories, Ministry of Health, Jerusalem, Israel

The effect of Escherichia coli heat-stable toxin (ST) on the intestinal trans-epithelial elimina-tion of ciprofloxacin was studied in the rabbit model. Following a systemic 27 mg/kg dose, excreted amounts of ciprofloxacin during the 2 h experiment were: 9.3 (± 4.8); 12.5 (± 5.2) and 0.3 (± 0.1) µg/cm2 surface of intestinal wall in ST-challenged jejunal, ileal and caecal loops, respectively. In control loops the corresponding amounts were: 5.0 (± 2.8), 6.5 (± 3.4) and 0.3 (± 0.1) µg/cm2, respectively. The trans-epithelial elimination of ciprofloxacin was significantly higher in ST-challenged small bowel loops than in controls while caecal elimination was negligible.

* Corresponding author. Tel: +972-3-5345389; Fax: +972-3-5347081; E-mail: unit{at}netvision.net.il


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