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Journal of Antimicrobial Chemotherapy (2001) 47, 671-674
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Activities of cholic acid-derived antimicrobial agents against multidrug-resistant bacteria

Erica J. Schmidta, J. Scott Boswella, Joshua P. Walsha, Matthew M. Schellenberga, Timothy W. Wintera, Chunhong Lib, Glenn W. Allmana and Paul B. Savageb,*

a Departments of Microbiology and b Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA

Cationic cholic acid derivatives displayed potent and broad-spectrum activity against multidrug-resistant Gram-negative and -positive bacteria. Specific examples were effective permeabilizers of the outer membranes of many strains of multidrug-resistant Gram-negative bacteria and sensitized these to hydrophobic antibiotics. We also prepared a new cholic acid derivative with improved apparent selectivity for prokaryote membranes.

* Corresponding author. Tel: +1-801-378-4020; Fax: +1-801-378-5474; E-mail: paul_savage{at}byu.edu


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