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Journal of Antimicrobial Chemotherapy (2001) 47, 459-461
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea

Jae J. Kima,b, Rita Reddyb, Miae Leeb, Jong G. Kimc, Fouad A. K. El-Zaatarib, Michael S. Osatob, David Y. Grahamb and Dong H. Kwonb,*

a Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; c Internal Medicine, Korea University College of Medicine, Seoul, Korea; b Department of Medicine Baylor College of Medicine, Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA

Antibiotic resistance in Helicobacter pylori varies according to geographical region. We studied the primary resistance rates among 652 H. pylori isolated from Korea in relation to collection date, disease presentation, age and gender. Resistance rates were 40.6% (metronidazole), 5.9% (clarithromycin), 5.3% (tetracycline), 0% (amoxycillin), 1.5% (furazolidone) and 1.5% (nitrofurantoin). Resistance to metronidazole and clarithromycin increased from 1994 to 1999 (from 33.3 to 47.7% and 4.8 to 7.7%, respectively), but the differences only reached significance when rates of metronidazole resistance in women were compared with those in men (48.6 versus 36.9%).

* Corresponding author. Tel: +1-713-794-7276; Fax: +1-713-795-4471; E-mail: dkwon{at}bcm.tmc.edu


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