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Journal of Antimicrobial Chemotherapy (2001) 47, 417-420
© 2001 The British Society for Antimicrobial Chemotherapy

Treatment alternatives for Mycobacterium kansasii

John R. Graybilla,b,* and Rosie Bocanegraa

a Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78284; b Infectious Diseases Service, Box 111F, Veterans Administration Hospital, 7400 Merton Minter Blvd, San Antonio, TX 78284, USA

Mycobacterium kansasii was administered intravenously to congenitally athymic (nude) mice. Beginning 1 week later, rifapentine, azithromycin, ethambutol or combined therapy was initiated orally. All three drugs were highly active individually. Although there was no evidence of antagonism, combined therapy was not more effective than either component used alone.

* Correspondence address. Infectious Diseases Service, Box 111F, Veterans Administration Hospital, 7400 Merton Minter Blvd, San Antonio, TX 78284, USA. Tel: +1-210-615-111; Fax: +1-210-614-6197; E-mail: graybill{at}uthscsa.edu


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