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Journal of Antimicrobial Chemotherapy (2001) 47, 141-146
© 2001 The British Society for Antimicrobial Chemotherapy

The effect of fosfomycin on neutrophil function

Robert Krausea,*, Sanda Patrutab, Florian Daxböcka,,b, Petra Fladerera and Christoph Wenischa

a Division of Infectious Diseases, Department of Medicine, Karl-Franzens University Graz, Auenbruggerplatz 15, A-8036 Graz, Austria; b Division of Infectious Diseases, Department of Internal Medicine I, University Hospital Vienna, Austria

Fosfomycin (cis-1,2-epoxypropyl phosphonic acid) is a cell wall synthesis-inhibiting antibiotic. We investigated the effect of fosfomycin on several indices of neutrophil function. Neutrophil phagocytosis was analysed by flow cytometry. Cytosolic calcium kinetics were assessed fluorometrically and neutrophil bactericidal ability was assessed by fluorescence microscopy. Intracellular reactive oxygen intermediate (ROI) production was analysed by flow cytometry and extracellular ROI by cytochrome c reductase assay. After fosfomycin incubation, phagocytosis was unaffected as assessed by the FACS assay. Fosfomycin incubation resulted in enhanced bactericidal ability, in increased intracellular calcium concentrations, elevated extracellular ROI production and decreased chemotaxis but it did not affect intracellular ROI production and chemokinesis.

* Corresponding author. Tel: +43-316-385-2274; Fax: +43-316-385-3062; E-mail: robert.krause{at}kfunigraz.ac.at


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