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Journal of Antimicrobial Chemotherapy (2001) 47, 97-99
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Activity of buforin II alone and in combination with azithromycin and minocycline against Cryptosporidium parvum in cell culture

Andrea Giacometti*, Oscar Cirioni, Maria Simona Del Prete, Francesco Barchiesi, Anna Fineo and Giorgio Scalise

Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy

The in vitro anti-cryptosporidial activity of buforin II alone and in combination with azithromycin and minocycline was investigated. Buforin II showed moderate activity, which increased with increasing concentration to 55.7% suppression of growth at 20 µM. Moreover, its activity was enhanced when it was combined with either azithromycin or minocycline with >90% parasite reduction at the highest concentration tested. Buforin II may be active in inhibiting Cryptosporidium parvum growth in vitro upon combination with either azithromycin or minocycline.

* Correspondence address: Clinica Malattie Infettive—c/o Azienda Ospedaliera Umberto I, Piazza Cappelli 1, I-60121 Ancona, Italy. Tel: +39-071-596-3467; Fax: +39-071-596-3468; E-mail: cmalinf{at}popcsi.unian.it


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