Journal of Antimicrobial Chemotherapy (2001) 47, 115-116
© 2001 The British Society for Antimicrobial Chemotherapy
Correspondence |
MLS resistance phenotypes and mechanisms in ß-haemolytic group B, C and G Streptococcusisolates in La Rioja, Spain
a Area Bioquímica y Biología Molecular, Universidad de La Rioja, Madre de Dios 51, 26006 Logroño, Spain; b Laboratorio Microbiología, Hospital San Millán, Logroño, Spain
Sir,
Two main mechanisms of resistance to macrolidelincosamide-streptogramin (MLS) antibiotics have been described in group B (GBS), group C (GCS) and group G (GGS) ß-haemolytic streptococci. Target site modification by rRNA methylases, encoded by erm genes, confers the MLSB resistance phenotype [erythromycin-resistant clindamycin resistant (ERYR-CLIR)]. The mechanism of active efflux confers a dissociate M resistance phenotype [erythromycin-resistantclindamycin-susceptible (ERYR-CLIS)]. The objective of the present study was to determine the incidence of MLS resistance in vitro among 136 GBS, eight GCS and 28 GGS consecutive clinical isolates recovered from the Hospital San Millán
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