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Journal of Antimicrobial Chemotherapy (2001) 47, 113-115
© 2001 The British Society for Antimicrobial Chemotherapy

Correspondence

Development of chromosomally encoded resistance mutations in small-colony variants of Staphylococcus aureus

Franz-Josef Schmitza,b,*, Ad C. Fluitb, Andreas Beecka, Mirella Perdikoulia and Christof von Eiffc

a Institute for Medical Microbiology and Virology, Heinrich-Heine Universität Düsseldorf, Germany; b Eijkman-Winkler Institute for Medical Microbiology, University Medical Center Utrecht, The Netherlands; c Institute of Medical Microbiology, Westfälische Wilhelms-Universität, Münster, Germany

Sir,

Small-colony variants (SCVs) represent subpopulations of Staphylococcus aureus and are frequently auxotrophic for either menadione or haemin, compounds required in the biosynthesis of menaquinone and cytochromes, which are components of the electron transport chain. The decrease in electron transport activity seen in these auxotrophic SCVs may provide a mechanism of persistence within host tissues and may account for their resistance in vitro to a variety of antibiotics.1

Fluoroquinolone, rifampicin and low-level mupirocin resistance in S. aureus is chromosomally encoded, based mainly on mutations in the . . . [Full Text of this Article]

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