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Journal of Antimicrobial Chemotherapy (2000) 46, 951-957
© 2000 The British Society for Antimicrobial Chemotherapy

The ß-lactamases and ß-lactam antibiotic susceptibility of Yersinia enterocolitica

Jeannette N. Phama, Sydney M. Bella,*, Liliane Martinb and Elisabeth Carnielb

a Department of Microbiology, The Prince of Wales Hospital, Randwick, NSW 2031, Australia; b WHO Yersinia Collaborating Centre, Institut Pasteur, 75724 Paris Cedex 15, France

One hundred and forty-five isolates of Yersinia enterocolitica of different serotypes and biotypes, including atypical biotypes, collected from various parts of the world, were examined for their susceptibility to ß-lactam antibiotics and expression of intracellular ß-lactamases. The reasons for the specificity of patterns of susceptibility to ß-lactams for each biotype or subtype of Y. enterocolitica were elucidated by examining their ß-lactamase activity. Whilst the biotypes and subtypes were uniformly susceptible to the newer ß-lactam antibiotics, the susceptibility pattern observed with other ß-lactams was specific to each biotype or subtype, because of the characteristics of ß-lactamase expression by strains within these groups. The susceptibility to these ß-lactam agents depended entirely on the extent of elaboration or the absence of one of the two ß-lactamases, enzyme A and enzyme B, found in the species. Detection of enzyme B by a disc diffusion test yielded inconsistent results, but detection of enzyme A by disc diffusion was highly reliable. This test clearly distinguished strains of biotype 2, serotype O:5,27 from those of biotype 2, serotype O:9 and biotype 3, serotypes O:1, 2a-3, O:3 and O:5.

* Corresponding author. Tel: +43-612-9382-9053; Fax: +43-612-9382-9098; E-mail: smbell{at}unsw.edu.au


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