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Journal of Antimicrobial Chemotherapy (2000) 46, 901-904
© 2000 The British Society for Antimicrobial Chemotherapy

Combined effects of meropenem and aminoglycosides on Pseudomonas aeruginosa in vitro

Atsushi Nakamuraa,*, Masayoshi Hosodaa, Takashi Katoa, Yasuo Yamadaa, Makoto Itoha, Katsunori Kanazawab and Hiroshi Noudab

a First Department of Internal Medicine, Nagoya City University, Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan; b Sumitomo Pharmaceuticals Research Center, 3-1-98 Kasugadenaka, Konohana-ku, Osaka 554-0022, Japan

To investigate combinations of antibiotics against Pseudomonas aeruginosa, the in vitro effects of combinations of meropenem with each of three aminoglycosides, arbekacin, amikacin and netilmicin, were evaluated using an agar dilution chequerboard technique. The combinations of meropenem and aminoglycosides were effective against almost all P. aeruginosa strains tested, which included meropenem-resistant strains. Increased synergic effects were observed in combinations that included arbekacin or amikacin. None of the combinations had an antagonistic effect. Most of the synergic and additive effects were achieved at clinically relevant concentrations.

* Corresponding author. Tel: +81-52-853-8211; Fax: +81-52-852-0952; E-mail: anakamur{at}med.nagoya-cu.ac.jp


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