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Journal of Antimicrobial Chemotherapy (2000) 46, 1017-1022
© 2000 The British Society for Antimicrobial Chemotherapy

Brief report

The in vitro activity of ABT773, a new ketolide antimicrobial agent

J. M. Andrews, T. M. A. Weller*, J. P. Ashby, R. M. Walker and R. Wise

Department of Medical Microbiology, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QH, UK

The in vitro activity of ABT773, a ketolide antimicrobial agent, was investigated and compared with those of seven other antibiotics. Type strains and 733 Gram-positive, Gram-negative and anaerobic isolates of clinical origin and four Chlamydia isolates were used. The activity of ABT773 was very similar to that of telithromycin, the other ketolide tested. The MIC90 was <= 0.5 mg/L for all bacteria examined except methicillin-resistant Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Haemophilus influenzae and Bacteroides spp. The antichlamydial activity of ABT773 was greater than that of telithromycin, erythromycin and ciprofloxacin. Neither an increase in the size of the inoculm nor the addition of human serum had any marked affect on the in vitro activity of ABT773.

* Corresponding author. Tel: +44-121-507-5742; Fax: +44-121-551-7763; E-mail: T.M.A.Weller{at}bham.ac.uk


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