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Journal of Antimicrobial Chemotherapy (2000) 46, 839-842
© 2000 The British Society for Antimicrobial Chemotherapy

Brief report

Pharmacokinetics of a parenteral carbapenem, biapenem, in patients with end-stage renal disease and influence of haemodialysis

Satoru Nagashimaa,b, Osamu Kozawaa, Takanobu Otsukac, Ken-ichi Kohnoa,b, Masahiko Minamotod, Masahiro Yokokawad, Mitsutaka Kanamarub and Toshihiko Uematsua,*

a Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, b Shitoro Clinic, Hamamatsu 432-8066, c Department of Orthopedic Surgery, Nagoya City University School of Medicine, Nagoya 467-8601 and d Wyeth-Lederle Japan Ltd, Tokyo 175-0082, Japan

The effects of haemodialysis on the pharmacokinetics of a carbapenem, biapenem, were evaluated in five patients with end-stage renal disease, who received 1 h iv infusions of 300 mg biapenem on both the days on and off 4 h haemodialysis. With haemodialysis, plasma biapenem exhibited two elimination phases, one during and the other after haemodialysis with half-lives of 1.16 ± 0.12 and 3.33 ± 0.91 h, respectively. Ninety percent of biapenem was removed from blood to dialysate. Without haemodialysis, plasma biapenem was mono-exponentially eliminated with a half-life of 4.35 ± 1.30 h.

* Corresponding author. Tel: +81-58-267-2231; Fax: +81-58-267-2959; E-mail: uematsu{at}cc.gifu-u.ac.jp


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