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Journal of Antimicrobial Chemotherapy (2000) 46, 835-837
© 2000 The British Society for Antimicrobial Chemotherapy

Brief report

A novel method for collecting and detecting amoxycillin in urine: a tool for testing antibiotic compliance in the community

Wei Shen Lima, Sarah Ganderb, Roger G. Finchb and John T. Macfarlanea,*

a Respiratory Medicine and b Department of Infectious Diseases, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK

Assessing compliance to prescribed antibiotics in community studies of respiratory tract infections is difficult. We describe a simple method for collecting and detecting amoxycillin in urine using urine dip-sticks in conjunction with a bioassay. Urine was collected at timed intervals from eight healthy volunteers following oral amoxycillin administration. Dip-sticks inoculated with urine collected 1 and 8 h after antibiotic resulted in mean zones of inhibition of 1.75 and 1.37 cm, respectively. Amoxycillin activity remained demonstrable 14 days after inoculation of dip-sticks with urine. Dip-sticks inoculated with urine from control subjects who had not taken amoxycillin did not cause inhibition.

* Corresponding author. Tel: + 44-115-9691169, ext. 46723; Fax: + 44-115-9627723.


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