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Journal of Antimicrobial Chemotherapy (2000) 46, 823-826
© 2000 The British Society for Antimicrobial Chemotherapy

Brief report

Impact of a new quinolone, DU-6859a, and two oral carbapenems, CS-834 and L-084, on the rat and mouse caecal microflora

Cheng-Xu Liua, Naoki Katoa,*, Kunitomo Watanabea, Tadashi Sakatab and Tsutomu Kanekob

a Institute of Anaerobic Bacteriology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705 and b Central Research Institute, Meiji Milk Product Co., Tokyo 189-8530, Japan

We determined the influence of a new quinolone, DU-6859a, and two oral carbapenems, CS-834 and L-084, on the rat and mouse caecal microflora. The caecum–skin fistula-implanted rats and conventional mice were given oral antimicrobials at doses of 30 mg/kg bid for 5 days. DU-6859a generated a marked decrease in the numbers of caecal flora except for enterococci. CS-834 and L-084 had little impact on the rat caecal flora. CS-834 caused a great decrease in the numbers of mouse caecal flora but L-084 did not. In vitro studies suggest that the difference is due to the extension of inactivation of antimicrobials by caecum contents.

* Corresponding author. Fax: +81-58-265-9001; E-mail: nk19{at}cc.gifu-u.ac.jp


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