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Journal of Antimicrobial Chemotherapy (2000) 46, 625-628
© 2000 The British Society for Antimicrobial Chemotherapy

Brief report

Simple 1,2-aminoalcohols as strain-specific antimalarial agents

Joshua Howarth* and David G. Lloyd

School of Chemical Sciences, Dublin City University, Dublin 9, Ireland

We report here the in vitro activity of a selection of 1,2-aminoalcohol-containing compounds against cloned strains of human Plasmodium falciparum. These compounds exhibit moderate antimalarial activity but a high degree of strain specificity, preferentially inhibiting a chloroquine-resistant strain of the organism.

*Corresponding author. Tel: +353-1-7045312; Fax: +353-1-7045503; E-mail: howarthj{at}ccmail.dcu.ie


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