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Journal of Antimicrobial Chemotherapy (2000) 46, 613-616
© 2000 The British Society for Antimicrobial Chemotherapy

Brief report

Clarithromycin resistance stability in Helicobacter pylori: influence of the MIC and type of mutation in the 23S rRNA

Teresa Alarcón*, Diego Domingo, Nuria Prieto and Manuel López-Brea

Department of Microbiology, Hospital Universitario de la Princesa, Diego de León 62, 28006 Madrid, Spain

Thirty clarithromycin-resistant Helicobacter pylori strains (MIC range 8–64 mg/L) were subcultured in a drug-free medium and the MIC was determined every five passages to detect in vitro stability of resistance. Three out of the 30 (10%) lost their resistance after 10, 13 or 18 subcultures (MIC decrease from 8 to 0.008, from 16 to 0.064 and from 32 to 0.016 mg/L). The effect of four macrolides at subinhibitory concentrations on the development of resistance was studied in H. pylori NCTC 11638 and TIGR 26695. A change in the MIC was observed only when NCTC11638 was exposed to 0.5 x MIC of erythromycin for 20 days.

* Corresponding author. Tel: +34-91-520-23-17; Fax: +34-91-309-00-47; E-mail: talarcon{at}helicobacterspain.com


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