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Journal of Antimicrobial Chemotherapy (2000) 46, 457-459
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Eradication of non-typhoid salmonellae in acute enteritis after therapy with ofloxacin for 5 or 10 days

Pål Voltersvika,*, Alfred Halstensenb, Nina Langelandb, Asbjørn Digranesc, Lars Erik Petersond, Tore Rolstade and Claus Ola Solbergb

a Department of Infectious Diseases Prevention, City of Bergen; b Institute of Medicine and c Department of Microbiology and Immunology, The Gade Institute, University of Bergen, Bergen, Norway; d Department of Statistics, University of Gøteborg, Gothenburg, Sweden; e Hoechst Marion Roussel, Oslo, Norway

Eradication of non-typhoid salmonellae was evaluated in a randomized, double-blinded study of 49 patients with acute enteritis after therapy with ofloxacin 400 mg once daily for 5 or 10 days. Early eradication of salmonellae was found in 57% of patients in the 5 day therapy group and in 74% of patients in the 10 day therapy group. This difference was larger among severely ill patients. Together with our previous study of ofloxacin therapy for 3 days or placebo, this shows that early eradication of non-typhoid salmonellae increases with duration of ofloxacin therapy without an increase in persistence of salmonellae in stools or development of resistant strains.

* Correspondence address. Centre for Research in Virology, Department of Microbiology and Immunology, The Gade Institute, University of Bergen, PO Box 7800, N-5020 Bergen, Norway. Tel: +47-55584510; Fax: +47-55584512; E-mail: pal.voltersvik{at}vir.uib.no


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